Description

6-Iodouracil is a halogenated pyrimidine derivative, a key heterocyclic building block in organic synthesis and pharmaceutical research. This compound matters for its role as a versatile intermediate in the development of nucleoside analogs, antiviral agents, and potential radiopharmaceuticals. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on oncology, virology, and diagnostic imaging applications.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel nucleoside analogs and antiviral drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving thymidylate synthase and other pyrimidine metabolism pathways.
• Radiopharmaceutical Development: Serves as a starting material for iodine-123 or iodine-131 labeled compounds used in diagnostic imaging and therapy.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Stille) to introduce the iodouracil moiety into more complex molecular architectures.
• Anticancer Agent Research: Investigated for its potential incorporation into DNA-targeting prodrugs and chemotherapeutic agents.
• Agrochemical Research: Used in the development of novel pesticides and herbicides that target plant nucleotide synthesis.

Basic Information

Product Name	6-Iodouracil
CAS No.	4269-94-7
Molecular Formula	C4H3IN2O2
Molecular Weight	237.98 g/mol
Synonyms	2,4(1H,3H)-Pyrimidinedione, 5-iodo-; 5-Iodouracil; 5-Iodo-2,4-dihydroxypyrimidine; 5-Iodopyrimidine-2,4(1H,3H)-dione; NSC 38297; 6-Iodo-1H-pyrimidine-2,4-dione; 5-Iodo-1H-pyrimidine-2,4-dione
EINECS	224-247-4

Quality Control

Our 6-Iodouracil is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets high-purity standards suitable for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent any potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	~300°C (dec.)
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.