Description

L-Proline, 4-Hydroxy-1-Methyl-, trans- is a non-proteinogenic, hydroxylated proline derivative with a specific stereochemical configuration. This compound is a valuable chiral building block and intermediate in the synthesis of complex bioactive molecules, offering precise control over stereochemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for developing novel compounds and active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for protease inhibitors and other biologically active peptides.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies and as a standard in analytical method development for amino acid analysis.
• Agrochemical Synthesis: Serves as a precursor in the design and production of advanced herbicides, fungicides, or plant growth regulators with specific stereochemical requirements.
• Peptide Chemistry: Incorporated into custom peptides to study structure-activity relationships (SAR) or to confer specific conformational properties.
• Fine Chemical Production: Employed in the asymmetric synthesis of complex organic molecules for various high-value industrial applications.

Basic Information

Product Name	L-Proline, 4-Hydroxy-1-Methyl-, trans-
CAS No.	4252-82-8
Molecular Formula	C₆H₁₁NO₃
Molecular Weight	145.16 g/mol
Synonyms	(2S,4R)-4-Hydroxy-1-methylproline; trans-4-Hydroxy-1-methyl-L-proline; 1-Methyl-4-hydroxy-L-proline; (2S,4R)-1-Methyl-4-hydroxyproline; 4-Hydroxy-1-methyl-L-proline; Allo-4-hydroxy-1-methylproline; L-1-Methyl-4-hydroxyproline; Hydroxymethylproline
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Hydroxy-1-Methyl-, trans- is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (trans isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.