Description

2-Trifluoromethyl-3H-Benzoimidazol-5-Ylaminedihydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its specific trifluoromethylated benzimidazole core structure. This compound is of significant commercial value for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular modifications. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new drug candidates and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug molecules, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Biochemical Probe Synthesis: Serves as a precursor for creating labeled compounds and probes used in biochemical assays and diagnostic research.
• Material Science: Potential intermediate in the synthesis of specialty polymers and organic electronic materials due to its conjugated benzimidazole system.
• Contract Research & Development (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic and fluoroorganic chemistry.

Basic Information

Product Name	2-Trifluoromethyl-3H-Benzoimidazol-5-Ylaminedihydrochloride
CAS No.	4205-97-4
Molecular Formula	C8H8Cl2F3N3
Molecular Weight	274.07 g/mol
Synonyms	5-Amino-2-(trifluoromethyl)-1H-benzimidazole Dihydrochloride; 2-(Trifluoromethyl)-1H-benzimidazol-5-amine Dihydrochloride; 5-Amino-2-trifluoromethylbenzimidazole Dihydrochloride; 2-Trifluoromethyl-5-aminobenzimidazole Dihydrochloride; 4205-97-4; 2-Trifluoromethyl-1H-benzo[d]imidazol-5-amine Dihydrochloride; Benzimidazole, 5-amino-2-(trifluoromethyl)-, dihydrochloride
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-3H-Benzoimidazol-5-Ylaminedihydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.