Description

4-Amino-2,3,5,6-Tetrafluorotoluene is a high-value fluorinated aromatic amine building block, prized for its unique combination of electron-withdrawing fluorine atoms and a reactive amino group. This structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where enhanced stability, lipophilicity, and metabolic resistance are required. It is primarily sought by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing new compounds with tailored properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides with improved environmental stability and efficacy.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display and lighting technologies.
• Polymer & Resin Modifier: Incorporated to enhance chemical resistance, thermal stability, and surface properties of high-performance polymers.
• Dye & Pigment Intermediate: Employed in the production of specialized, light-fast colorants.
• Cross-coupling Reactions: Valuable substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to create complex biaryl structures.

Basic Information

Item	Details
Product Name	4-Amino-2,3,5,6-Tetrafluorotoluene
CAS No.	4127-63-3
Molecular Formula	C7H5F4N
Molecular Weight	179.12 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-methylaniline; 4-Methyl-2,3,5,6-tetrafluoroaniline; 4-Amino-2,3,5,6-tetrafluoro-1-methylbenzene; 2,3,5,6-Tetrafluoro-p-toluidine; Perfluorotoluidine (ambiguous, contact for specific isomer); TFT Amine; 4-Amino-α,α,α,α-tetrafluorotoluene
EINECS	Contact for details

Quality Control

Our 4-Amino-2,3,5,6-Tetrafluorotoluene is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and GC-MS, to ensure it meets the high standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.