Description

n-Acetyl-L-Leucine Ethyl Ester is a protected derivative of the essential amino acid L-Leucine, widely utilized as a key chiral building block in organic synthesis. This high-purity intermediate is critical for ensuring the stereochemical integrity and efficacy of final active pharmaceutical ingredients (APIs) and bioactive peptides. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and biotechnology companies engaged in the development of novel therapeutics and complex organic molecules.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the multi-step synthesis of peptide-based drugs and other bioactive compounds.
• Peptide Synthesis: Used in Solid-Phase Peptide Synthesis (SPPS) and solution-phase methods to incorporate leucine residues while protecting the amine functionality.
• Biochemical Research: Serves as a standard or reagent in metabolic studies and enzymatic research involving amino acid derivatives.
• Asymmetric Synthesis: Employed in the preparation of non-natural amino acids and other enantiomerically pure molecules for medicinal chemistry.
• Cosmetic Peptides: A potential intermediate in the synthesis of certain peptide sequences used in advanced skincare formulations.

Basic Information

Product Name	n-Acetyl-L-Leucine Ethyl Ester
CAS No.	4071-36-7
Molecular Formula	C10H19NO3
Molecular Weight	201.26 g/mol
Synonyms	L-Leucine, N-acetyl-, ethyl ester; Ethyl N-acetyl-L-leucinate; Ac-Leu-OEt; N-Acetyl-L-leucine ethyl ester; (S)-Ethyl 2-acetamido-4-methylpentanoate; N-Acetylleucine ethyl ester; Nα-Acetyl-L-leucine ethyl ester; 2-Acetamido-4-methylpentanoic acid ethyl ester
EINECS	223-777-7

Quality Control

Our n-Acetyl-L-Leucine Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for pharmaceutical and research applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Optical Rotation [α]20/D	-20° to -24° (c=1 in ethanol)
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.