Description

3,4-Dehydro-L-Proline is a non-proteinogenic cyclic amino acid derivative characterized by an unsaturated pyrrolidine ring. This unique structure makes it a valuable chiral building block and intermediate in advanced organic synthesis. It is primarily utilized in pharmaceutical research for the development of novel bioactive compounds, including enzyme inhibitors and peptidomimetics. Researchers in medicinal chemistry and fine chemical synthesis rely on this high-purity intermediate for its defined stereochemistry and reactivity.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the research and development of new drug candidates, particularly protease inhibitors and other targeted therapies.
• Peptidomimetics Research: Used to introduce conformational constraints into peptide analogs, enhancing their metabolic stability and binding affinity.
• Biochemical Tool Compound: Serves as a substrate or inhibitor in enzymatic studies to probe biological pathways and mechanisms.
• Fine Chemical Synthesis: Employed in asymmetric synthesis to construct complex, stereodefined molecules for agrochemical and material science applications.
• Academic & R&D: Fundamental building block in university and institutional research for exploring new synthetic methodologies and chemical biology.

Basic Information

Product Name	3,4-Dehydro-L-Proline
CAS No.	4043-88-3
Molecular Formula	C5H7NO2
Molecular Weight	113.11 g/mol
Synonyms	(2S)-3,4-Didehydropyrrolidine-2-carboxylic acid; L-3,4-Dehydroproline; δ3,4-L-Proline; (S)-3,4-Dihydro-2H-pyrrole-2-carboxylic acid; 3,4-Didehydro-L-proline; 3,4-Dehydroproline; (S)-3,4-Dehydroproline
EINECS	223-752-8

Quality Control

Our 3,4-Dehydro-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specific test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.