Description

D-Pyroglutamic Acid is a high-purity, non-proteinogenic amino acid derivative with significant stereochemical importance. This compound is valued for its role as a versatile chiral building block and intermediate in sophisticated organic synthesis. It is essential for industries focused on pharmaceutical development, advanced biochemical research, and the synthesis of specialized peptides and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of various active pharmaceutical ingredients (APIs), prodrugs, and novel therapeutic compounds.
• Peptide Synthesis: Used as a building block for constructing complex peptides and peptidomimetics, where its specific stereochemistry is critical for biological activity.
• Biochemical Research: Employed in enzymatic studies, metabolic pathway analysis, and as a standard in chromatographic analysis for amino acid derivatives.
• Cosmetic & Personal Care: Incorporated into formulations for its potential skin-conditioning and moisturizing properties, often in high-end skincare products.
• Fine Chemical Synthesis: Serves as a starting material or intermediate for synthesizing flavors, fragrances, and other specialty organic molecules.
• Asymmetric Catalysis: Utilized in the development and study of chiral catalysts and ligands for stereoselective reactions.

Basic Information

Product Name	D-Pyroglutamic Acid
CAS No.	4042-36-8
Molecular Formula	C5H7NO3
Molecular Weight	129.11 g/mol
Synonyms	(R)-(-)-2-Pyrrolidone-5-carboxylic Acid; (R)-5-Oxoproline; D-(-)-Pyroglutamic Acid; (R)-Pyroglutamic Acid; D-PCA; (R)-2-Pyrrolidinone-5-carboxylic Acid; D-5-Oxopyrrolidine-2-carboxylic Acid; (R)-Pyroglutamate
EINECS	223-742-2

Quality Control

Our D-Pyroglutamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical and research applications. Certificates of Analysis (COA) detailing specific results for identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	-10.0° to -12.0° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.