Description

Ac-Leu-Gly-Oh CAS NO 4033-42-5 is a protected tripeptide derivative, specifically an N-acetylated leucine-glycine dipeptide with a free carboxylic acid terminus. This compound serves as a crucial synthetic intermediate and building block in advanced peptide chemistry and pharmaceutical research. It is primarily utilized by research institutions and manufacturers in the life sciences sector for developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: A key building block for the solid-phase and solution-phase synthesis of longer, more complex peptide sequences targeting various biological pathways.
• Biochemical Research: Used in enzymatic studies, substrate specificity assays, and as a standard or reference compound in analytical method development for peptide analysis.
• Prodrug Development: The acetyl (Ac) protecting group and specific amino acid sequence make it a candidate for designing peptide-based prodrugs to enhance drug delivery and bioavailability.
• Chemical Biology Tool: Incorporated into probes or inhibitors to study protein-protein interactions, enzyme mechanisms, and cellular signaling processes.
• Custom Peptide Synthesis: Supplied to contract research and manufacturing organizations (CROs/CMOs) for the production of bespoke peptides for client projects.

Basic Information

Product Name	Ac-Leu-Gly-Oh
CAS No.	4033-42-5
Molecular Formula	C10H18N2O4
Molecular Weight	230.26 g/mol
Synonyms	N-Acetyl-L-leucylglycine; Acetyl-leucyl-glycine; N-Acetyl-Leu-Gly-OH; L-Leucine, N-acetyl-, glycyl-; Ac-Leu-Gly; N-Acetyl-Leu-Gly; Ac-L-Leu-Gly-OH; N-Acetyl-L-leucylglycine
EINECS	Contact for details

Quality Control

Our Ac-Leu-Gly-Oh is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, residual solvents, and other critical parameters to ensure compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	-30° to -40° (c=1 in Acetic Acid)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.