Description

L-Canaline Base is a non-proteinogenic amino acid analog of L-ornithine, known for its potent inhibitory activity against ornithine transcarbamylase and pyridoxal phosphate-dependent enzymes. This compound serves as a critical biochemical tool and a versatile chiral building block in advanced organic synthesis. It is primarily utilized by researchers in pharmaceutical development, agrochemical research, and academic institutions focusing on enzyme kinetics and metabolic pathway studies.

Application

• Biochemical Research: Used as a specific, irreversible inhibitor of ornithine transcarbamylase (OTC) in studies of the urea cycle and amino acid metabolism.
• Pharmaceutical Intermediates: Acts as a key chiral synthon for the synthesis of novel drug candidates, particularly those targeting enzyme pathways.
• Agrochemical Development: Employed in research for creating new plant growth regulators or herbicides based on its antimetabolite properties.
• Enzyme Mechanism Studies: A valuable probe for investigating the mechanism of pyridoxal phosphate (PLP)-dependent enzymes due to its structural similarity to ornithine.
• Nutritional Science Research: Used in studies examining amino acid antagonism and the effects of non-proteinogenic amino acids in biological systems.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	L-Canaline Base
CAS No.	496-93-5
Molecular Formula	C4H10N2O2
Molecular Weight	118.14 g/mol
Synonyms	L-2-Amino-4-(aminooxy)butyric acid; (S)-2-Amino-4-(aminooxy)butanoic acid; L-α-Amino-γ-(aminooxy)-n-butyric acid; Canaline; L-Canaline; O-Amino-L-homoserine; γ-Aminooxy-L-α-aminobutyric acid
EINECS	207-831-2

Quality Control

Our L-Canaline Base is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-Isomer)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.