Description

2,5-Difluorobenzyl Chloride is a versatile and reactive organofluorine building block essential for advanced chemical synthesis. Its value lies in the strategic placement of fluorine atoms and a reactive chloromethyl group, enabling precise molecular modifications to enhance the properties of target compounds. This intermediate is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials sectors for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates where fluorine substitution can improve metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging the fluorine atoms to enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, where fluorine atoms help tune electronic properties and improve performance.
• Polymer & Resin Modification: Employed to introduce fluorinated benzyl groups into polymer chains, altering surface properties, chemical resistance, and thermal stability.
• Cross-coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl structures common in many advanced materials.
• Chemical Research & Development: An important reagent for medicinal chemistry and process chemistry research, enabling the exploration of new chemical spaces and synthetic routes.

Basic Information

Product Name	2,5-Difluorobenzyl Chloride
CAS No.	495-07-8
Molecular Formula	C7H5ClF2
Molecular Weight	162.56 g/mol
Synonyms	1-(Chloromethyl)-2,5-difluorobenzene; α-Chloro-2,5-difluorotoluene; (2,5-Difluorophenyl)methyl Chloride; 2,5-Difluoro-α-chlorotoluene; 2,5-Difluorobenzylchloride; Benzene, 1-(chloromethyl)-2,5-difluoro-; 2,5-DFBC
EINECS	207-806-5

Quality Control

Our 2,5-Difluorobenzyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent decomposition. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.30 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.