Description

o-Sialic Acid CAS NO 489-46-3 is a specific isomer of sialic acid, a family of nine-carbon sugars critical for biological recognition processes. This high-purity compound is essential for research and development in glycobiology and the synthesis of advanced biomaterials. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and diagnostic reagent industries for applications ranging from drug discovery to the development of novel therapeutics and vaccines.

Application

• Glycobiology Research: A key substrate and standard for studying sialic acid metabolism, enzyme kinetics (sialidases, sialyltransferases), and glycan biosynthesis pathways.
• Pharmaceutical Intermediates: Serves as a crucial building block for the chemical and enzymatic synthesis of sialylated glycoconjugates, glycoproteins, and gangliosides with therapeutic potential.
• Diagnostic Reagent Development: Used in the production of calibration standards and reagents for assays detecting sialic acid levels, which can be biomarkers for certain diseases.
• Biomaterial Functionalization: Employed to introduce bio-recognition motifs onto surfaces, nanoparticles, or polymers to enhance biocompatibility and target-specific interactions.
• Nutritional Science Studies: Applied in research investigating the role of sialylated compounds in infant nutrition and cognitive development.
• Virology and Vaccine Research: Utilized in studies of viral pathogenesis, as sialic acids are often receptors for influenza viruses and other pathogens, aiding in vaccine and antiviral drug design.

Basic Information

Product Name	o-Sialic Acid
CAS No.	489-46-3
Molecular Formula	C11H19NO9
Molecular Weight	309.27 g/mol
Synonyms	5-Acetamido-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic Acid; (5S)-5-Acetamido-3,5-dideoxy-D-glycero-α-D-galacto-non-2-ulopyranosonic Acid; O-Acetylneuraminic Acid; N-Acetylneuraminic Acid (common name for the family); Neu5Ac; Sia; NANA
EINECS	207-716-3

Quality Control

Our o-Sialic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and specific impurities to ensure it meets rigorous research and production standards. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Specific Rotation	-30° to -35° (c=1 in H2O)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.