Description

Angiotensin I, Human is a linear decapeptide hormone that serves as the direct precursor to the potent vasoconstrictor Angiotensin II. This compound is of critical importance in the renin-angiotensin-aldosterone system (RAAS), a key regulator of blood pressure and fluid balance. It is an essential biochemical tool for researchers and manufacturers in the pharmaceutical and life sciences sectors, particularly for studying cardiovascular physiology, developing diagnostic assays, and screening for novel therapeutic agents targeting hypertension and related disorders.

Application

• Biochemical Research: Fundamental studies on the renin-angiotensin system, enzyme kinetics (e.g., ACE activity), and hormone precursor processing.
• Pharmaceutical Development: A critical reference standard and substrate in the research and development of angiotensin-converting enzyme (ACE) inhibitors and other cardiovascular drugs.
• Diagnostic Assay Production: Used as a calibrated antigen or standard in the manufacture of immunoassay kits (e.g., ELISA, RIA) for measuring renin or angiotensin I levels in clinical and research settings.
• Enzyme Activity Testing: Serves as the specific substrate for in vitro assays measuring plasma renin activity (PRA), a key diagnostic parameter.
• Cell Culture & Physiology Studies: Investigation of peptide hormone effects on vascular smooth muscle cells, cardiac cells, and other relevant tissue models.

Basic Information

Product Name	Angiotensin I, Human
CAS No.	484-42-4
Molecular Formula	C62H89N17O14
Molecular Weight	1296.5 g/mol
Synonyms	Angiotensin I; Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu; DRVYIHPFHL; Human Angiotensin I; Angiotensinogen (1-10); Hypertension I
EINECS	207-613-7

Quality Control

Our Angiotensin I, Human is produced and tested under stringent quality management systems. Each batch is subjected to comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from multiple orthogonal methods such as HPLC for purity, mass spectrometry for identity confirmation, and amino acid analysis. Our quality commitment supports applications requiring high-purity research and diagnostic standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by amino acid analysis)
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.