Description

4-(Trifluoromethylsulfonyl)Aniline is a high-value fluorinated aromatic building block characterized by its unique combination of an aniline group and a strongly electron-withdrawing trifluoromethanesulfonyl substituent. This structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where enhanced stability and specific electronic properties are required. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with tailored functionalities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas requiring fluorinated motifs for metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides that benefit from the chemical and biological stability imparted by the trifluoromethylsulfonyl group.
• Material Science: Serves as a precursor for functional dyes, pigments, and advanced polymers where the introduction of fluorine atoms modifies optical and electronic properties.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for catalysis and molecular recognition applications in organic synthesis.
• Research & Development: A versatile reagent in academic and industrial R&D for exploring new chemical spaces and reaction pathways in medicinal and synthetic chemistry.

Basic Information

Product Name	4-(Trifluoromethylsulfonyl)Aniline
CAS No.	473-27-8
Molecular Formula	C7H6F3NO2S
Molecular Weight	225.19 g/mol
Synonyms	4-Aminophenyl trifluoromethyl sulfone; 4-(Trifluoromethylsulfonyl)benzenamine; p-(Trifluoromethylsulfonyl)aniline; 1-Amino-4-(trifluoromethylsulfonyl)benzene; Benzenamine, 4-[(trifluoromethyl)sulfonyl]-; 4-Trifluoromethanesulfonylaniline; α,α,α-Trifluoro-4-aminobenzenesulfonamide
EINECS	207-475-8

Quality Control

Our 4-(Trifluoromethylsulfonyl)Aniline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed when not in use to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.