Description

4-(Trifluoromethoxy)Aniline is a versatile fluorinated aromatic amine building block, essential for introducing the trifluoromethoxy aniline moiety into complex molecular structures. Its primary value lies in enabling the synthesis of advanced materials and active compounds with enhanced properties such as metabolic stability and lipophilicity. This high-purity intermediate is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the trifluoromethoxy group improves biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Used in the production of fluorinated components for electronic display materials, enhancing their dielectric anisotropy and thermal stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart unique chemical resistance, lower surface energy, and improved durability.
• Dye & Pigment Intermediate: Serves as a starting material for synthesizing advanced, light-fast fluorinated dyes and organic pigments.
• Cross-coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for creating complex aromatic amines.

Basic Information

Product Name	4-(Trifluoromethoxy)Aniline
CAS No.	461-82-5
Molecular Formula	C7H6F3NO
Molecular Weight	177.12 g/mol
Synonyms	4-Aminophenyl trifluoromethyl ether; p-(Trifluoromethoxy)aniline; 1-Amino-4-(trifluoromethoxy)benzene; 4-Trifluoromethoxyaniline; 4-Aminophenyl trifluoromethyl ether; α,α,α-Trifluoro-p-anisidine; Aniline, 4-(trifluoromethoxy)-
EINECS	207-324-4

Quality Control

Our 4-(Trifluoromethoxy)Aniline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade starting materials and adherence to global regulatory standards like REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere (e.g., nitrogen or argon) to preserve stability and prevent discoloration. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.