Description

Trifluoromethanesulfonanilide is a specialized organofluorine compound that serves as a versatile building block and reagent in advanced chemical synthesis. Its value lies in the unique reactivity imparted by the trifluoromethanesulfonyl (triflyl) group attached to an aniline nitrogen, making it a key precursor for pharmaceuticals, agrochemicals, and materials science. This high-purity intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the triflyl moiety or aniline derivatives into complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly those requiring sulfonamide or aniline functionalities with enhanced metabolic stability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides where the trifluoromethylsulfonyl group contributes to biological activity and environmental persistence.
• Organic Synthesis Reagent: Acts as a triflylating agent or a protected aniline derivative in multi-step synthetic routes for complex organic molecules.
• Material Science Precursor: Employed in the synthesis of specialty polymers, ligands for catalysis, and advanced materials requiring specific fluorine-containing aromatic units.
• Research & Development: A valuable compound for medicinal chemistry and process chemistry research in academic and industrial laboratories.

Basic Information

Product Name	Trifluoromethanesulfonanilide
CAS No.	456-64-4
Molecular Formula	C7H6F3NO2S
Molecular Weight	225.19 g/mol
Synonyms	N-Phenyltrifluoromethanesulfonamide; Trifluoromethanesulfonic acid anilide; Anilinium triflate; Trifluoromethanesulfonaniline; Benzenamine, N-[(trifluoromethyl)sulfonyl]-; TfNHPh; Triflylaniline
EINECS	Contact for details

Quality Control

Our Trifluoromethanesulfonanilide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of our industrial and research clients. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee reliable performance in your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.