Description

3-(Fluoromethyl)Aniline CAS NO 456-46-2 is a versatile fluorinated aromatic amine building block, characterized by its reactive aniline group and a fluoromethyl substituent. This unique structure makes it a critical intermediate for synthesizing advanced molecules where the introduction of fluorine enhances properties like metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical sectors. Its utility extends to materials science for creating specialized polymers and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom improves efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Incorporated as a monomer or cross-linking agent to create specialty polymers with enhanced chemical resistance and thermal stability.
• Dye & Pigment Manufacturing: Intermediate for producing fluorinated dyes and pigments that offer superior brightness and color fastness.
• Chemical Research & Development: A valuable reagent in academic and industrial labs for exploring new fluorination chemistry and creating novel compound libraries.

Basic Information

Product Name	3-(Fluoromethyl)Aniline
CAS No.	456-46-2
Molecular Formula	C7H8FN
Molecular Weight	125.14 g/mol
Synonyms	3-(Fluoromethyl)benzenamine; m-(Fluoromethyl)aniline; 3-Aminobenzyl fluoride; 1-Amino-3-(fluoromethyl)benzene; Benzenamine, 3-(fluoromethyl)-; α-Fluoro-m-toluidine; m-Aminobenzyl fluoride; (3-Aminophenyl)methyl fluoride
EINECS	Contact for details

Quality Control

Our production of 3-(Fluoromethyl)Aniline adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity, potency, and impurity profiles. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials such as strong oxidizing agents and acids. For long-term storage, consider using an inert atmosphere to minimize oxidation risk.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.