Description

3-Fluorobenzyl Chloride is a versatile and reactive organofluorine building block essential for advanced chemical synthesis. Its molecular structure, featuring both a reactive benzyl chloride group and a fluorine substituent, makes it a critical intermediate for introducing fluorinated benzyl motifs into target molecules. This compound is particularly valuable for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new compounds with enhanced biological activity, metabolic stability, or specific physical properties.

Application

• Pharmaceutical Intermediate: Key starting material for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring a fluorobenzyl moiety to modulate pharmacokinetics and receptor binding.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atom can improve lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Polymer & Resin Modifier: Incorporated into specialty polymers to alter thermal stability, chemical resistance, or surface properties.
• Cross-coupling Reactions: Utilized in palladium-catalyzed reactions like Suzuki or Buchwald-Hartwig amination for constructing complex biaryl structures.
• Derivatization Agent: Acts as an alkylating agent in organic synthesis to introduce the 3-fluorobenzyl protecting group or functional handle.

Basic Information

Product Name	3-Fluorobenzyl Chloride
CAS No.	456-42-8
Molecular Formula	C7H6ClF
Molecular Weight	144.57 g/mol
Synonyms	α-Chloro-3-fluorotoluene; 1-(Chloromethyl)-3-fluorobenzene; 3-Fluorophenylmethyl Chloride; m-Fluorobenzyl Chloride; (3-Fluorophenyl)methyl Chloride; 3-Fluorobenzylchloride; 3-Fluoro-benzylchlorid
EINECS	Contact for details

Quality Control

Our 3-Fluorobenzyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for industrial and research applications, ensuring reliable performance in your critical synthesis processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, oxidizing agents, and sources of ignition. Recommended storage temperature is 2-8°C for extended stability. The product is moisture-sensitive and should be handled under an inert atmosphere for optimal shelf life.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density	~1.22 g/cm³ at 20°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.