Description

3,5-Dihydroxybenzotrifluoride (CAS NO 454-68-2) is a versatile trifluoromethylated aromatic diol, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both phenolic hydroxyl groups and a highly electron-withdrawing trifluoromethyl group, makes it an invaluable intermediate for creating compounds with tailored properties. This high-purity chemical is essential for research and production in the pharmaceutical, agrochemical, and specialty materials sectors, where it is used to introduce fluorine motifs that enhance metabolic stability, lipophilicity, and overall performance.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and anti-inflammatory agents.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Core monomer for producing fluorine-containing polymers and small molecules used in electronic displays and organic light-emitting diodes (OLEDs).
• Polymer Modification: Used to incorporate fluorine into polymer backbones, enhancing chemical resistance, thermal stability, and surface properties of high-performance plastics and coatings.
• Dye & Pigment Manufacturing: Intermediate for synthesizing specialized fluorinated dyes and pigments with improved lightfastness and color properties.
• Cross-Coupling Reactions: Valuable substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.

Basic Information

Product Name	3,5-Dihydroxybenzotrifluoride
CAS No.	454-68-2
Molecular Formula	C7H5F3O2
Molecular Weight	178.11 g/mol
Synonyms	3,5-Bis(trifluoromethyl)phenol (incorrect but common misnomer); 3,5-Dihydroxy-α,α,α-trifluorotoluene; 1,3-Dihydroxy-5-(trifluoromethyl)benzene; 5-(Trifluoromethyl)resorcinol; Benzotrifluoride, 3,5-dihydroxy-; α,α,α-Trifluoro-3,5-dihydroxytoluene; 3,5-Dihydroxybenzotrifluoride; 3,5-Dihydroxy(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 3,5-Dihydroxybenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. Certificates of Analysis (COA) with full traceability are provided for every shipment, and we support compliance with relevant regulatory frameworks including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. Due to its phenolic nature, it is recommended to handle and store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.