Description

Homocysteine is a sulfur-containing, non-proteinogenic amino acid that serves as a critical intermediate in the metabolic pathways of methionine and cysteine. Its precise measurement and availability are essential for research into cardiovascular health, neurological disorders, and metabolic conditions. This high-purity compound is primarily utilized by pharmaceutical R&D laboratories, diagnostic kit manufacturers, and academic institutions conducting biochemical and clinical studies.

Application

• Clinical Diagnostics & Research: A key biomarker in kits and assays for measuring plasma homocysteine levels, linked to cardiovascular risk assessment.
• Pharmaceutical Development: Used as a reference standard and an intermediate in the research and synthesis of novel therapeutic agents targeting homocysteine-related pathologies.
• Nutritional & Metabolic Studies: Employed in in-vitro studies to investigate the impact of vitamins B6, B12, and folate on homocysteine metabolism.
• Biochemical Research: Serves as a crucial substrate or inhibitor in enzymatic studies related to transsulfuration and remethylation pathways.
• Quality Control: Acts as a certified reference material (CRM) for calibrating analytical equipment like HPLC and LC-MS in diagnostic and quality control laboratories.

Basic Information

Product Name	Homocysteine
CAS No.	454-28-4
Molecular Formula	C4H9NO2S
Molecular Weight	135.19 g/mol
Synonyms	L-Homocysteine; (S)-2-Amino-4-mercaptobutyric acid; 2-Amino-4-sulfanylbutanoic acid; Hcy; DL-Homocysteine; Homocysteine free base; 2-Amino-4-mercaptobutyric acid
EINECS	207-222-9

Quality Control

Our Homocysteine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and diagnostic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated methods such as HPLC, NMR, and elemental analysis. We support compliance with relevant pharmacopeial guidelines and cGMP standards where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Specific range available on COA
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.