Description

2-Fluoro-4-Methylphenol is a versatile fluorinated phenolic compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a fluorine atom and a methyl group on the phenol ring, makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is essential for research and production in the pharmaceutical, agrochemical, and specialty materials sectors, where precise chemical functionality is required.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring fluorinated aromatic systems to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to introduce fluorine-containing phenolic groups into polymer chains, enhancing properties like chemical resistance, surface energy, and thermal performance.
• Dye & Pigment Manufacturing: Acts as an intermediate for synthesizing specialized fluorinated dyes and pigments with unique color fastness and spectral properties.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination chemistry and developing novel synthetic methodologies.

Basic Information

Product Name	2-Fluoro-4-Methylphenol
CAS No.	452-81-3
Molecular Formula	C7H7FO
Molecular Weight	126.13 g/mol
Synonyms	2-Fluoro-p-cresol; 4-Methyl-2-fluorophenol; 2-Fluoro-4-methylphenol; 2-Fluoro-4-cresol; 2-Fluoro-4-hydroxytoluene; o-Fluoro-p-cresol; 2-Fluoro-4-methyl-1-hydroxybenzene; 452-81-3
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Methylphenol is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chromatography (HPLC, GC) and spectroscopy (IR, NMR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all test results are provided with each shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen) for long-term preservation. Keep away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents, strong bases, and acid chlorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	32 - 36 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.