Description

4-Fluoro-3-Methylphenol is a versatile fluorinated phenolic compound that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both a fluorine atom and a methyl group on the phenol ring, makes it a valuable intermediate for creating molecules with tailored electronic and steric properties. This high-purity chemical is essential for research and development, as well as commercial production, in the pharmaceutical, agrochemical, and specialty materials sectors.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates targeting the central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor for fluorinated mesogens, which are critical components in high-performance liquid crystal displays (LCDs) and optical devices.
• Polymer Modification: Acts as a monomer or functionalizing agent to introduce fluorine into polymer backbones, improving chemical resistance, thermal stability, and surface properties.
• Dye and Pigment Manufacturing: Employed in the synthesis of specialized fluorinated dyes and pigments that offer superior lightfastness and color properties.
• Chemical Research: A valuable reagent in academic and industrial R&D for studying structure-activity relationships and developing new fluorination methodologies.

Basic Information

Product Name	4-Fluoro-3-Methylphenol
CAS No.	452-70-0
Molecular Formula	C7H7FO
Molecular Weight	126.13 g/mol
Synonyms	3-Methyl-4-fluorophenol; 4-Fluoro-m-cresol; 4-Fluoro-3-methylphenol; 2-Fluoro-5-hydroxy-1-methylbenzene; 5-Fluoro-2-methylphenol; 3-Methyl-4-fluorophenol; 4-Fluoro-3-cresol; 452-70-0
EINECS	207-208-1

Quality Control

Our 4-Fluoro-3-Methylphenol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	45 - 50 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.