Description

4-Fluoro-2-Methoxyphenol is a versatile fluorinated phenolic compound, also known as 4-Fluoro-2-methoxyphenol CAS NO 450-93-1. It serves as a critical building block in advanced organic synthesis, valued for its unique combination of fluorine and methoxy substituents which impart specific electronic and steric properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a fluorinated aromatic moiety to modulate bioavailability, metabolic stability, and receptor binding affinity.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated monomers and polymers used in electronic displays and organic light-emitting diodes (OLEDs), contributing to improved charge transport and thermal stability.
• Polymer Modification: Employed to introduce fluorine-containing phenolic groups into polymer backbones, enhancing material properties such as chemical resistance, thermal stability, and surface characteristics.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments that offer superior lightfastness and unique color properties.
• Research & Development: Serves as a valuable reagent in academic and industrial R&D for exploring new fluorination chemistry and developing novel chemical entities.

Basic Information

Product Name	4-Fluoro-2-Methoxyphenol
CAS No.	450-93-1
Molecular Formula	C7H7FO2
Molecular Weight	142.13 g/mol
Synonyms	4-Fluoro-2-methoxyphenol; 2-Methoxy-4-fluorophenol; 4-Fluoro-2-hydroxyanisole; 4-Fluoroguaiacol; 2-Hydroxy-5-fluoroanisole; 5-Fluoro-2-methoxyphenol; 4-Fluorocatechol monomethyl ether; Guaiacol, 4-fluoro-
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Methoxyphenol is produced under a stringent quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our commitment to cGMP principles and relevant ISO standards ensures a reliable supply of high-purity material for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	40 - 44 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.