Description

2,3-Difluorobenzyl Chloride is a versatile and reactive organofluorine building block essential for advanced chemical synthesis. Its value lies in the strategic placement of fluorine atoms on the aromatic ring, which significantly influences the electronic properties and metabolic stability of final compounds. This intermediate is critically needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) drugs and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoro motif enhances biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays.
• Organic Light-Emitting Diodes (OLEDs): Acts as a starting material for electron-transport or host materials in OLED device fabrication.
• Fluorinated Polymer Chemistry: Employed to introduce benzyl and fluorine functionalities into specialty polymers to modify thermal and chemical resistance.
• Cross-Coupling Reactions: The benzyl chloride moiety makes it a suitable substrate for palladium-catalyzed cross-coupling reactions to construct complex biaryl structures.

Basic Information

Product Name	2,3-Difluorobenzyl Chloride
CAS No.	446-57-1
Molecular Formula	C7H5ClF2
Molecular Weight	162.56 g/mol
Synonyms	α-Chloro-2,3-difluorotoluene; 1-(Chloromethyl)-2,3-difluorobenzene; (2,3-Difluorophenyl)methyl Chloride; 2,3-Difluoro-α-chlorotoluene; 2,3-DFBC; Benzene, 1-(chloromethyl)-2,3-difluoro-; 2,3-Difluorobenzylchloride
EINECS	Contact for details

Quality Control

Our 2,3-Difluorobenzyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing purity, identity, and impurity profiles as determined by GC, HPLC, and NMR. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, and we support our partners with the documentation required for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.