Description

2-Amino-5-Chlorobenzotrifluoride is a versatile halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its trifluoromethyl and chloro substituents impart unique electronic and steric properties, making it a high-value intermediate for creating complex molecules. This compound is essential for research and production in the pharmaceutical and agrochemical sectors, where it is used to develop active ingredients with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system and anti-inflammatory applications.
• Agrochemical Synthesis: Building block for manufacturing advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Dye and Pigment Manufacturing: Used in the production of specialized, light-fast dyes and pigments for industrial applications.
• Liquid Crystal & OLED Materials: Intermediate in the creation of fluorinated compounds for electronic display materials and organic light-emitting diodes.
• Polymer Chemistry: Monomer or modifier for synthesizing specialty polymers with specific thermal and chemical resistance properties.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for constructing complex aromatic amines.

Basic Information

Product Name	2-Amino-5-Chlorobenzotrifluoride
CAS No.	445-03-4
Molecular Formula	C7H5ClF3N
Molecular Weight	195.57 g/mol
Synonyms	5-Chloro-2-aminobenzotrifluoride; 2-Amino-α,α,α-trifluoro-5-chlorotoluene; 5-Chloro-α,α,α-trifluoro-o-toluidine; 2-Amino-5-chloro-α,α,α-trifluorotoluene; 5-Chloro-2-(trifluoromethyl)aniline; Benzenamine, 5-chloro-2-(trifluoromethyl)-; 5-Chloro-α,α,α-trifluoro-2-methylaniline
EINECS	207-161-7

Quality Control

Our 2-Amino-5-Chlorobenzotrifluoride is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, ensuring full traceability and compliance with your R&D or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	64 - 68 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.