Description

4-Fluoro-α-Cyclopropyl-α-(4-Fluorophenyl)-Benzylic Alcohol is a high-value fluorinated synthetic intermediate characterized by its unique benzylic alcohol and cyclopropyl structural motifs. This compound is critical for pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) and complex organic molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing sophisticated molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, including potential CNS agents and enzyme inhibitors.
• Agrochemical Research: Used in developing novel pesticides and herbicides where the fluorinated cyclopropyl group enhances biological activity and stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts in asymmetric synthesis.
• Material Science: Potential monomer or additive for creating specialty polymers with tailored properties.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying biological systems and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial scale-up projects.

Basic Information

Product Name	4-Fluoro-α-Cyclopropyl-α-(4-Fluorophenyl)-Benzylic Alcohol
CAS No.	427-53-2
Molecular Formula	C16H14F2O
Molecular Weight	260.28 g/mol
Synonyms	α-Cyclopropyl-4-fluoro-α-(4-fluorophenyl)benzenemethanol; 1-(4-Fluorophenyl)-1-cyclopropyl-2-(4-fluorophenyl)ethanol; 4-Fluoro-α-cyclopropyl-α-(4-fluorophenyl)benzyl Alcohol; Benzenemethanol, α-cyclopropyl-4-fluoro-α-(4-fluorophenyl)-; (4-Fluorophenyl)(4-fluorophenyl)(cyclopropyl)methanol; 427-53-2; FCB Intermediate
EINECS	Contact for details

Quality Control

Our 4-Fluoro-α-Cyclopropyl-α-(4-Fluorophenyl)-Benzylic Alcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, and custom purity grades (e.g., >98%, >99%) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.