Description

3',5'-Difluoroacetanilide is a high-purity fluorinated aromatic intermediate of significant importance in advanced organic synthesis. This compound is valued for its role as a key building block in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by R&D chemists and process development scientists for constructing active pharmaceutical ingredients (APIs) and specialty fine chemicals. Its defined structure, referenced by CAS NO 404-01-3, ensures consistency and reliability in sensitive synthetic pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those containing difluorophenyl motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic electronic materials, contributing to the performance of displays and lighting.
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering their surface properties, chemical resistance, and durability.
• Chemical Research & Development: A versatile reagent in academic and industrial labs for exploring new fluorination reactions and creating specialized chemical libraries.
• Dye & Pigment Manufacturing: Acts as an intermediate in the production of specialized fluorinated dyes and pigments with unique color fastness and properties.

Basic Information

Product Name	3',5'-Difluoroacetanilide
CAS No.	404-01-3
Molecular Formula	C8H7F2NO
Molecular Weight	171.15 g/mol
Synonyms	N-(3,5-Difluorophenyl)acetamide; 1-Acetamido-3,5-difluorobenzene; 3,5-Difluoroacetanilide; Acetamide, N-(3,5-difluorophenyl)-; 3,5-Difluoroaniline, N-acetyl derivative; NSC 406109; AI3-52220; LS-165881
EINECS	Contact for details

Quality Control

Our 3',5'-Difluoroacetanilide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to confirm identity and quantify impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications met. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	145 - 149 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.