Description

3-Amino-5-(Trifluoromethyl)Phenol is a high-value trifluoromethylated aromatic amine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining an electron-donating amino group with the strong electron-withdrawing trifluoromethyl group, makes it indispensable for creating compounds with tailored electronic and physical properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and anticancer compounds.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Used in the development of advanced electronic display materials and organic light-emitting diodes (OLEDs) due to its ability to modify charge transport and emission properties.
• Dye & Pigment Manufacturing: Intermediate for producing specialized dyes and pigments with improved lightfastness and color properties for industrial applications.
• Polymer Modification: Serves as a functional monomer or cross-linking agent to introduce amino and phenolic groups into polymer chains, enhancing adhesion, thermal stability, or reactivity.
• Research & Development: A valuable reagent in academic and industrial R&D for exploring new chemical entities and reaction pathways in medicinal and materials chemistry.

Basic Information

Product Name	3-Amino-5-(Trifluoromethyl)Phenol
CAS No.	401-86-5
Molecular Formula	C7H6F3NO
Molecular Weight	177.12 g/mol
Synonyms	5-Amino-3-hydroxybenzotrifluoride; 3-Hydroxy-5-(trifluoromethyl)aniline; 3-Amino-5-(trifluoromethyl)benzenol; 5-(Trifluoromethyl)-3-aminophenol; 3-Amino-α,α,α-trifluoro-m-cresol; m-Amino-α,α,α-trifluoro-m-hydroxybenzene; 401-86-5; Phenol, 3-amino-5-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 3-Amino-5-(Trifluoromethyl)Phenol is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for advanced synthesis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical specifications. Our quality commitment ensures batch-to-batch consistency for your most demanding R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.