Description

4-Hydroxy-3-Nitrobenzotrifluoride is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring both a nitro group and a trifluoromethyl substituent on a phenolic ring, makes it a critical building block for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the agrochemical and pharmaceutical sectors for the development of novel active ingredients.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of modern herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Pharmaceutical Synthesis: Serves as a crucial building block for developing active pharmaceutical ingredients (APIs), particularly in creating molecules with improved metabolic stability and bioavailability.
• Dye and Pigment Manufacturing: Used in the production of specialized dyes and pigments, where the nitro and hydroxy groups contribute to color formation and fastness properties.
• Liquid Crystal and Electronic Materials: Employed in the synthesis of advanced materials for electronic displays and organic semiconductors due to its aromatic and fluorinated structure.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl systems for various applications.

Basic Information

Product Name	4-Hydroxy-3-Nitrobenzotrifluoride
CAS No.	400-99-7
Molecular Formula	C7H4F3NO3
Molecular Weight	207.11 g/mol
Synonyms	3-Nitro-4-(trifluoromethyl)phenol; 4-Hydroxy-3-nitro-α,α,α-trifluorotoluene; 2-Nitro-α,α,α-trifluoro-p-cresol; 2-Nitro-4-(trifluoromethyl)phenol; 4-(Trifluoromethyl)-2-nitrophenol; NSC 404087; 4-Hydroxy-3-nitrobenzotrifluoride
EINECS	206-937-1

Quality Control

Our 4-Hydroxy-3-Nitrobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets precise customer specifications and industry standards. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging.

Specification

Item	Specification
Appearance	Yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	78 - 82 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.