Description

2-Amino-3-Bromo-5-Nitrobenzotrifluoride 95+% is a high-purity, multi-functional aromatic intermediate characterized by its trifluoromethyl, nitro, bromo, and amino substituents. This unique combination of functional groups makes it a versatile and valuable building block for the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and life science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology drugs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for advanced organic materials, including liquid crystals, organic semiconductors, and specialty polymers.
• Dye and Pigment Chemistry: Acts as an intermediate for synthesizing complex, high-performance dyes and pigments.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create more complex biaryl structures.
• Fluorinated Compound Library: Essential for medicinal chemistry programs focused on building libraries of fluorinated compounds to explore structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	2-Amino-3-Bromo-5-Nitrobenzotrifluoride 95+%
CAS No.	400-66-8
Molecular Formula	C7H4BrF3N2O2
Molecular Weight	285.02 g/mol
Synonyms	3-Bromo-2-amino-5-nitrobenzotrifluoride; 2-Amino-3-bromo-5-nitro-α,α,α-trifluorotoluene; 3-Bromo-2-amino-5-nitro-α,α,α-trifluorotoluene; 2-Amino-3-bromo-5-nitrobenzylidynetrifluoride; 1-Amino-2-bromo-6-nitro-4-(trifluoromethyl)benzene; Benzenamine, 3-bromo-2-nitro-5-(trifluoromethyl)-; 3-Bromo-2-nitro-5-(trifluoromethyl)aniline
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-3-Bromo-5-Nitrobenzotrifluoride undergoes rigorous analytical testing to ensure it meets the specified purity and identity criteria. Our quality assurance process includes modern chromatographic and spectroscopic techniques to verify composition and detect impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.