Description

1-(3-Hydroxypropyl)-2-Phenyl-5,6,7,8-Tetrahydroquinazoline-4(1H)-Thione is a specialized heterocyclic organic compound featuring a tetrahydroquinazoline core. This molecule is of significant interest in advanced pharmaceutical research and development due to its unique structural framework, which serves as a versatile scaffold for creating novel bioactive agents. Key industries that require this high-purity intermediate include pharmaceutical R&D, agrochemical synthesis, and academic research institutions focused on medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, or oncology.
• Medicinal Chemistry Research: Used as a privileged scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Agrochemical Development: Acts as a precursor in the research and synthesis of new crop protection agents and pesticides.
• Chemical Biology Probe: Utilized in the development of molecular probes to study enzyme function and biological pathways.
• Academic & Contract Research: Employed in university laboratories and CROs (Contract Research Organizations) for fundamental research in organic and heterocyclic chemistry.
• Custom Synthesis: A starting material for the custom manufacturing of more complex, target-specific molecules for client-directed projects.

Basic Information

Product Name	1-(3-Hydroxypropyl)-2-Phenyl-5,6,7,8-Tetrahydroquinazoline-4(1H)-Thione
CAS No.	397879-67-3
Molecular Formula	C₁₇H₂₀N₂OS
Molecular Weight	300.42 g/mol
Synonyms	4(1H)-Thione, 1-(3-Hydroxypropyl)-2-phenyl-5,6,7,8-tetrahydroquinazoline; 2-Phenyl-1-(3-hydroxypropyl)-5,6,7,8-tetrahydro-4(1H)-quinazolinethione; 1-(3-Hydroxypropyl)-2-phenyl-4-thioxo-1,2,3,4,5,6,7,8-octahydroquinazoline; THQ-thione derivative; Quinazoline-4-thione derivative
EINECS	Contact for details

Quality Control

Our 1-(3-Hydroxypropyl)-2-Phenyl-5,6,7,8-Tetrahydroquinazoline-4(1H)-Thione is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maximize stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.