Description

Dabcyl-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Edans is a high-purity, synthetic peptide substrate designed for sensitive biochemical research and diagnostic applications. This compound is a critical tool for studying protease activity, particularly for enzymes like furin and related proprotein convertases, due to its specific cleavage sequence. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and diagnostic kit manufacturing sectors. Its reliable performance makes it essential for high-throughput screening, enzyme kinetics studies, and the development of novel therapeutic and detection assays.

Application

• Protease Activity Assays: As a fluorogenic substrate for monitoring the enzymatic activity of furin and other proprotein convertases in real-time.
• High-Throughput Screening (HTS): Used in drug discovery platforms to identify and characterize potential protease inhibitors.
• Biochemical Research: Fundamental tool for studying enzyme kinetics, specificity, and catalytic mechanisms in academic and industrial laboratories.
• Diagnostic Development: A key component in the formulation of diagnostic kits for detecting specific protease biomarkers associated with diseases.
• Quality Control in Biologics: Employed to assess the processing and purity of recombinant protein therapeutics that require specific protease cleavage.

Basic Information

Product Name	Dabcyl-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Edans
CAS No.	396716-14-6
Molecular Formula	C73H118N26O23S2
Molecular Weight	1680.0 g/mol (approximately)
Synonyms	Dabcyl-LAQAVRSSSR-Edans; Furin Fluorogenic Substrate; Dabcyl-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Edans Trifluoroacetate Salt; 5-((2-Aminoethyl)amino)naphthalene-1-sulfonic acid-(Dabcyl)-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-amide; EDANS/DABCYL Peptide Substrate; Proprotein Convertase Substrate; Fluorogenic Peptide Substrate 396716-14-6
EINECS	Contact for details

Quality Control

Every batch of Dabcyl-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Edans is manufactured under strict quality management systems. The product undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all relevant specifications to ensure it meets the rigorous standards required for research and in-vitro diagnostic (IVD) use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Water Content (KF)	≤ 8.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.