Description

n-Me-Abz-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2 is a synthetic, modified peptide sequence designed for advanced biochemical research and pharmaceutical development. This compound matters as a specialized tool for investigating protease activity, enzyme kinetics, and cellular signaling pathways, offering high specificity and purity for critical experiments. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on drug discovery, particularly in the fields of oncology and metabolic disease research. The product is supplied with a Certificate of Analysis to ensure batch-to-batch consistency for reliable scientific outcomes.

Application

• Protease Substrate Research: Used as a selective, fluorogenic, or chromogenic substrate for studying the activity and inhibition of specific proteases, including matrix metalloproteinases (MMPs).
• Biochemical Assay Development: Serves as a key component in the development of high-throughput screening (HTS) assays for drug discovery pipelines.
• Enzyme Kinetics Studies: Employed to determine kinetic parameters (Km, Vmax, kcat) and elucidate the mechanism of action of target enzymes.
• Cell Signaling Pathway Analysis: Utilized in cellular models to probe the role of specific proteolytic events in signal transduction and disease progression.
• Pharmaceutical Intermediate: Acts as a building block or a reference standard in the synthesis and quality control of novel therapeutic peptide candidates.
• Academic Research: Supports fundamental research in biochemistry, molecular biology, and medicinal chemistry at universities and government labs.

Basic Information

Item	Detail
Product Name	n-Me-Abz-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2
CAS No.	396716-07-7
Molecular Formula	C58H88N18O15
Molecular Weight	1253.4 g/mol
Synonyms	MMP Substrate; Abz-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2; N-Methylanthraniloyl-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-amide; Fluorogenic MMP-2/MMP-9 Substrate; Dnp-Peptide; Peptide Substrate 396716-07-7; Mca-PLGL-Dpa-AR-NH2 (related analog); Quenched Fluorescent Peptide Substrate
EINECS	Contact for details

Quality Control

Our n-Me-Abz-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-Nh2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity (typically >95%), mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support reproducible scientific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.