Description

5,6-Dihydroxy-2-Thiophen-2-Yl-Pyrimidine-4-Carboxylic Acid Methyl Ester is a high-purity heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its multifunctional pyrimidine-thiophene scaffold, which serves as a versatile precursor for the development of novel pharmacologically active compounds. This intermediate is primarily sought after by research institutions and pharmaceutical companies engaged in medicinal chemistry, specifically for the synthesis of potential drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its modifiable pyrimidine and thiophene rings.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, or insecticides, leveraging its heterocyclic structure.
• Material Science Research: Investigated as a monomer or precursor for the synthesis of specialized polymers or organic electronic materials with unique optoelectronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.

Basic Information

Product Name	5,6-Dihydroxy-2-Thiophen-2-Yl-Pyrimidine-4-Carboxylic Acid Methyl Ester
CAS No.	391680-92-5
Molecular Formula	C11H8N2O4S
Molecular Weight	264.26 g/mol
Synonyms	Methyl 5,6-dihydroxy-2-(thiophen-2-yl)pyrimidine-4-carboxylate; 2-(2-Thienyl)-5,6-dihydroxy-4-pyrimidinecarboxylic acid methyl ester; 5,6-Dihydroxy-2-(2-thienyl)-4-pyrimidinecarboxylic acid methyl ester; 4-Pyrimidinecarboxylic acid, 5,6-dihydroxy-2-(2-thienyl)-, methyl ester; 391680-92-5; Thiophene-pyrimidine derivative
EINECS	Contact for details

Quality Control

Our 5,6-Dihydroxy-2-Thiophen-2-Yl-Pyrimidine-4-Carboxylic Acid Methyl Ester is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.