Description

Fmoc-Pen(4-Meobzl)-Oh is a protected amino acid derivative, specifically an Fmoc (9-fluorenylmethoxycarbonyl)-protected penicillamine analog with a 4-methoxybenzyl (4-MeOBzl) side-chain protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of penicillamine into complex peptide chains. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated synthesis of peptides containing the non-proteinogenic amino acid penicillamine.
• Pharmaceutical Research: Used in the development of novel peptide-based drugs, enzyme inhibitors, and diagnostic agents.
• Bioconjugation & Labeling: Serves as a precursor for creating thiol-reactive probes or for introducing specific functional handles into peptides.
• Chemical Biology Studies: Employed in the synthesis of model peptides to study metal binding, protein folding, and disulfide bridge formation.
• Custom Peptide Services: A fundamental reagent for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide production.

Basic Information

Product Name	Fmoc-Pen(4-Meobzl)-Oh
CAS No.	387868-24-8
Molecular Formula	C27H27NO5S
Molecular Weight	477.57 g/mol
Synonyms	Fmoc-Pen(4-MeOBzl)-OH; Fmoc-S-p-methoxybenzyl-D-penicillamine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-[(4-methoxyphenyl)methyl]-D-penicillamine; Fmoc-D-Pen(4-MeOBzl)-OH; Fmoc-Penicillamine(4-MeOBzl)-OH; N-Fmoc-S-(4-methoxybenzyl)-D-penicillamine; Fmoc-D-Pen(p-MeOBzl)-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-methyl-3-[(4-methoxyphenyl)methylsulfanyl]butanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-Pen(4-Meobzl)-Oh is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for demanding research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.