Description

Fmoc-D-Dab(Aloc)-Oh is a protected amino acid derivative of high synthetic utility. This compound is essential for the solid-phase peptide synthesis (SPPS) of complex peptides, particularly where orthogonal protection strategies are required. It is a critical building block for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing peptide-based therapeutics and diagnostic agents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the controlled assembly of peptide chains, especially in Fmoc-based strategies.
• Orthogonal Protection Strategies: The Aloc (allyloxycarbonyl) side-chain protection allows for selective deprotection in the presence of other acid-labile protecting groups like Boc or base-labile groups like Fmoc.
• Synthesis of Modified Peptides: Used to incorporate the unnatural amino acid D-diaminobutyric acid (D-Dab) into peptide sequences, which can alter biological activity, stability, and conformation.
• Pharmaceutical Intermediate: Serves as a crucial intermediate in the research and development of novel peptide drugs, including antimicrobial peptides and hormone analogs.
• Bioconjugation and Labeling: The reactive carboxyl and protected amine groups make it suitable for creating custom linkers or labeled peptides for research applications.

Basic Information

Product Name	Fmoc-D-Dab(Aloc)-Oh
CAS No.	387824-78-4
Molecular Formula	C24H26N2O6
Molecular Weight	438.48 g/mol
Synonyms	Fmoc-D-2,4-diaminobutyric acid(Aloc)-OH; N-α-Fmoc-N-γ-Aloc-D-2,4-diaminobutyric acid; Fmoc-D-Dab(Aloc)-OH; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(((allyloxy)carbonyl)amino)butanoic acid; N-α-(9-Fluorenylmethoxycarbonyl)-N-γ-(allyloxycarbonyl)-D-2,4-diaminobutyric acid; Fmoc-D-Dab(Alloc)-OH; D-Dab(Aloc)-Fmoc
EINECS	Contact for details

Quality Control

Our Fmoc-D-Dab(Aloc)-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP manufacturing environments. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards to support our customers' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.