Description

Fmoc-D-Arg(Aloc)2-Oh CAS NO 387824-77-3 is a protected derivative of D-Arginine, specifically engineered for advanced solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity, stereochemically defined building blocks for complex peptide and protein mimetic development. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and CROs engaged in the discovery of novel therapeutic peptides, peptidomimetics, and bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of complex peptides, particularly where D-arginine incorporation is required.
• Pharmaceutical Research: Used in the discovery and development of novel peptide-based therapeutics, including antimicrobial peptides, hormone analogs, and targeted drug delivery systems.
• Peptidomimetic Design: Essential for creating stable peptide analogs with modified backbones or side chains to enhance metabolic stability and bioavailability.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-drug conjugates for diagnostic and therapeutic applications.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new bioactive peptide leads.
• Academic Research: A fundamental reagent in university and institutional labs studying protein-protein interactions, enzyme substrates, and signal transduction pathways.

Basic Information

Product Name	Fmoc-D-Arg(Aloc)2-Oh
CAS No.	387824-77-3
Molecular Formula	C30H37N5O6
Molecular Weight	563.65 g/mol
Synonyms	Fmoc-D-arginine(Aloc)2-OH; N-α-Fmoc-N-ω, N-ω'-bis(allyloxycarbonyl)-D-arginine; Fmoc-D-Arg(Alloc)2-OH; (2R)-5-[(Allyloxy)carbonyl]amino]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-NG,NG-bis(allyloxycarbonyl)pentanamide; Fmoc-D-Arg(Aloc)-OH (ambiguous, but common search term); D-Arg(Aloc)2-Fmoc; Fmoc-D-Arg(Alloc)-OH (Alloc protected); Protected D-Arginine Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-D-Arg(Aloc)2-Oh is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive pharmaceutical research. Each lot undergoes comprehensive analytical testing including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.