Description

4-Chloro-5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidine is a high-purity, heterocyclic organic compound that serves as a critical advanced intermediate in modern pharmaceutical research and development. Its unique fused-ring structure, incorporating chlorine and fluorine substituents, makes it a valuable scaffold for constructing novel bioactive molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other small-molecule drug candidates targeting various disease pathways.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its heterocyclic core for bioactivity.
• Chemical Biology Probe Development: Serves as a core structure for creating molecular probes to study enzyme function and cellular signaling processes.
• Material Science Research: Investigated as a precursor for organic electronic materials due to its conjugated π-system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	4-Chloro-5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidine
CAS No.	384351-45-5
Molecular Formula	C₁₂H₆ClFN₂S
Molecular Weight	264.70 g/mol
Synonyms	4-Chloro-5-(4-fluorophenyl)thieno[2,3-d]pyrimidine; 5-(4-Fluorophenyl)-4-chlorothieno[2,3-d]pyrimidine; Thieno[2,3-d]pyrimidine, 4-chloro-5-(4-fluorophenyl)-; 384351-45-5; 4-Chloro-5-(p-fluorophenyl)thieno[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 4-Chloro-5-(4-Fluorophenyl)Thieno[2,3-D]Pyrimidine is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided with each shipment, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.