Description

(Lys22)-Amyloid β-Protein (1-42) Trifluoroacetate Salt is a chemically modified peptide fragment of the amyloid-beta protein, a key molecule in neurological research. This specific variant, with a lysine substitution at position 22, is critical for studying the structural determinants, aggregation kinetics, and neurotoxic properties of amyloid-beta peptides in vitro. It is an essential research-grade biochemical for academic institutions, pharmaceutical R&D departments, and biotechnology companies focused on Alzheimer's disease pathogenesis, drug discovery, and diagnostic assay development.

Application

• Biochemical Research: Fundamental studies on the aggregation mechanisms, fibril formation, and structural biology of amyloid-beta peptides.
• Drug Discovery Screening: Used as a target substrate in high-throughput screening (HTS) assays to identify potential inhibitors of amyloid-beta aggregation or toxicity.
• Antibody & Assay Development: Serves as a critical antigen for the production and characterization of antibodies, and as a standard in ELISA, Western blot, and other immunoassays.
• Neurotoxicity Studies: Application in cell-based models (e.g., neuronal cell cultures) to investigate peptide-induced cytotoxicity and protective effects of candidate compounds.
• Biophysical Characterization: Analysis of peptide conformation and stability using techniques like circular dichroism (CD), nuclear magnetic resonance (NMR), and mass spectrometry.
• Reference Standard: Acts as a purified, characterized standard for quality control in related peptide synthesis and for calibrating analytical methods.

Basic Information

Product Name	(Lys22)-Amyloid β-Protein (1-42) Trifluoroacetate Salt
CAS No.	383200-59-7
Molecular Formula	C203H311N55O60S • xC2HF3O2
Molecular Weight	~4514.0 g/mol (free base)
Synonyms	Aβ(1-42) Lys22; Aβ42 (L22K); Amyloid Beta Peptide (1-42) (Lys22); Amyloid-β (1-42) Protein (Lys22); DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA (Lys22); Human Aβ(1-42) with K22 substitution; Lys22-Aβ42; (Lys22)-Aβ42 TFA salt
EINECS	Contact for details

Quality Control

Our research-grade peptides are manufactured and analyzed under strict quality protocols. Each batch of (Lys22)-Amyloid β-Protein (1-42) Trifluoroacetate Salt is characterized by advanced analytical techniques to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing HPLC purity, mass spectrometry (MS) confirmation, and endotoxin levels are provided with every shipment to support your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Aliquot into single-use vials after reconstitution to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Solubility	Soluble in 1% NH₄OH or DMSO, forms clear to slightly opalescent solution
Water Content (KF)	≤ 8.0%
Trifluoroacetate Content (HPLC)	≤ 15%
Endotoxin Level	< 100 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.