Description

n-(2-Morpholinoethyl)-5,6,7,8-Tetrahydrobenzo[4,5]Thieno[2,3-D]Pyrimidin-4-Amine CAS NO 381704-18-3 is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in kinase inhibitor research and development. It is primarily sought after by pharmaceutical R&D teams, biotechnology firms, and fine chemical manufacturers engaged in creating next-generation therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Biochemical Research: Used as a reference standard or a core scaffold in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Medicinal Chemistry: Serves as a versatile building block for constructing fused heterocyclic libraries for high-throughput screening against various biological targets.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	n-(2-Morpholinoethyl)-5,6,7,8-Tetrahydrobenzo[4,5]Thieno[2,3-D]Pyrimidin-4-Amine
CAS No.	381704-18-3
Molecular Formula	C₁₈H₂₄N₄OS
Molecular Weight	344.48 g/mol
Synonyms	4-[(2-Morpholin-4-ylethyl)amino]-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine; 381704-18-3; 4-Amino-N-(2-morpholinoethyl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine; 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amine, N-(2-morpholinoethyl)-; THTP-Morpholinoethylamine; Kinase Inhibitor Intermediate B3M
EINECS	Contact for details

Quality Control

Our n-(2-Morpholinoethyl)-5,6,7,8-Tetrahydrobenzo[4,5]Thieno[2,3-D]Pyrimidin-4-Amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for advanced research and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.