Description

(Ala1)-Par-4 (1-6) (Mouse) is a synthetic peptide fragment corresponding to the N-terminal region of the mouse Prostate Apoptosis Response-4 (Par-4) protein. This sequence-specific peptide is a critical research tool for studying the mechanisms of apoptosis and cell survival signaling pathways. It is primarily utilized by researchers and pharmaceutical developers in the fields of oncology, neurobiology, and molecular biology for in vitro and in vivo studies.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study Par-4 interaction with other proteins like PKCζ.
• Apoptosis Studies: Essential for investigating the selective induction of apoptosis in cancer cells, a key function of the full-length Par-4 protein.
• Signal Transduction Analysis: Employed to map and understand the SAC (Selective for Apoptosis in Cancer cells) domain activity and its role in cellular pathways.
• Antibody Production & Validation: Serves as a specific antigen for generating and testing antibodies against the Par-4 protein.
• Drug Discovery Screening: Used in high-throughput screening platforms to identify compounds that modulate Par-4 activity for potential therapeutic development.
• Cell Culture Experiments: Applied in cell-based assays to examine the effects of Par-4 fragments on proliferation, survival, and stress response.

Basic Information

Product Name	(Ala1)-Par-4 (1-6) (Mouse)
CAS No.	380900-00-5
Molecular Formula	C27H48N10O9
Molecular Weight	656.7 g/mol
Synonyms	Alanine-Par-4 (1-6) mouse; Par-4(1-6) (mouse) Ala1 analog; Mouse Par-4 N-terminal peptide (Ala1); AEEA-AAAAV; (Ala1)-Prostate Apoptosis Response-4 (1-6); Selective Apoptosis in Cancer cells (SAC) domain peptide fragment; PAWR (1-6) (mouse) analog
EINECS	Contact for details

Quality Control

Every batch of (Ala1)-Par-4 (1-6) (Mouse) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocols are designed to meet the exacting standards of life science research. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), molecular weight confirmation (by MS), and other relevant specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Molecular Weight	656.7 ± 1.0 Da (by MS)
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.