Description

2(1H)-Pyrimidinone,5-Acetyl-3,4-Dihydro-4-(4-Hydroxyphenyl)-6-Methyl-(9Ci) is a high-purity, synthetically derived heterocyclic compound belonging to the dihydropyrimidinone class. This advanced pharmaceutical intermediate is valued for its complex molecular architecture, which serves as a critical building block in modern medicinal chemistry. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other targeted small-molecule therapies.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Serves as a versatile building block for constructing more complex heterocyclic systems and fine chemicals.
• Biochemical Research: Employed in the study of enzyme-substrate interactions and as a tool compound in biochemical assays.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2(1H)-Pyrimidinone,5-Acetyl-3,4-Dihydro-4-(4-Hydroxyphenyl)-6-Methyl-(9Ci)
CAS No.	380654-22-8
Molecular Formula	C13H14N2O3
Molecular Weight	246.26 g/mol
Synonyms	5-Acetyl-3,4-dihydro-4-(4-hydroxyphenyl)-6-methyl-2(1H)-pyrimidinone; 5-Acetyl-4-(4-hydroxyphenyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one; 4-(4-Hydroxyphenyl)-5-acetyl-6-methyl-3,4-dihydro-2(1H)-pyrimidinone; 380654-22-8; Dihydropyrimidinone derivative; Biginelli reaction product; DHPM derivative
EINECS	Contact for details

Quality Control

Our 2(1H)-Pyrimidinone,5-Acetyl-3,4-Dihydro-4-(4-Hydroxyphenyl)-6-Methyl-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and detailed Certificates of Analysis (COA) to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.