Description

4-Ethoxy-2-Fluoroaniline Hydrochloride is a high-purity, functionalized aniline derivative that serves as a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific ethoxy and fluoro substituents into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in therapeutic areas requiring fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the 2-fluoro-4-ethoxy aniline moiety imparts desired biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for the synthesis of fluorinated aromatic diamines and other compounds used in electronic display technologies.
• Dyestuff & Pigment Intermediate: Employed in the manufacture of specialized azo dyes and high-performance pigments that benefit from the electron-donating ethoxy and halogen groups.
• Cross-Coupling Reactions: Acts as a valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) for creating complex amine derivatives.
• Chemical Research & Development: Utilized in academic and industrial R&D settings for exploring new synthetic methodologies and creating libraries of novel fluorinated compounds.

Basic Information

Product Name	4-Ethoxy-2-Fluoroaniline Hydrochloride
CAS No.	380430-46-6
Molecular Formula	C8H11ClFNO
Molecular Weight	191.63 g/mol
Synonyms	2-Fluoro-4-ethoxyaniline hydrochloride; 4-Ethoxy-2-fluoroaniline HCl; 4-Ethoxy-2-fluoro-benzenamine hydrochloride; 2-Fluoro-4-ethoxybenzenamine hydrochloride; 1-Amino-4-ethoxy-2-fluorobenzene hydrochloride; Aniline, 4-ethoxy-2-fluoro-, hydrochloride; 380430-46-6
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-2-Fluoroaniline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.