Description

5,7-Difluoroquinazolin-4(3H)-One is a high-purity fluorinated quinazolinone derivative, a critical advanced pharmaceutical intermediate. Its value lies in its role as a versatile building block for synthesizing novel, biologically active compounds, particularly kinase inhibitors. This product is essential for research and development laboratories and production facilities in the pharmaceutical and agrochemical industries, where precise molecular construction is paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted cancer therapies, especially tyrosine kinase inhibitors.
• Agrochemical Research: Used in developing new active ingredients for crop protection products.
• Chemical Biology: Serves as a core scaffold for designing and screening novel enzyme inhibitors in drug discovery programs.
• Organic Synthesis: A valuable fluorinated heterocyclic compound for constructing complex molecular architectures in medicinal chemistry.
• Academic & Contract Research: Utilized in university and CRO settings for fundamental research on heterocyclic chemistry and bioactivity.

Basic Information

Product Name	5,7-Difluoroquinazolin-4(3H)-One
CAS No.	379228-58-7
Molecular Formula	C8H4F2N2O
Molecular Weight	182.13 g/mol
Synonyms	5,7-Difluoro-3,4-dihydro-4-oxoquinazoline; 5,7-Difluoro-4(3H)-quinazolinone; 4(3H)-Quinazolinone, 5,7-difluoro-; 5,7-Difluoroquinazolin-4-ol; 379228-58-7; 5,7-Difluoro-4-hydroxyquinazoline
EINECS	Contact for details

Quality Control

Our 5,7-Difluoroquinazolin-4(3H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.