Description

Nemonoxacin is a novel, non-fluorinated quinolone antibiotic with potent broad-spectrum activity against Gram-positive and Gram-negative bacteria. Its unique chemical structure offers a valuable alternative in combating pathogens that have developed resistance to older generation fluoroquinolones. This advanced pharmaceutical intermediate is critical for research institutions and manufacturers developing next-generation antibacterial therapies targeting respiratory and skin infections.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of oral and potentially injectable antibiotic drugs.
• Antibacterial Research: A key reference standard and tool compound in microbiological and pharmacological studies of quinolone mechanisms.
• Drug Development: Serves as a core intermediate for synthesizing novel antibiotic candidates and prodrugs in preclinical and clinical development pipelines.
• Combination Therapies: Investigated for use in synergistic combination treatments to enhance efficacy and overcome bacterial resistance.
• Veterinary Medicine: Potential application in developing antibacterial treatments for animal health, subject to regulatory approval.

Basic Information

Product Name	Nemonoxacin
CAS No.	378746-64-6
Molecular Formula	C₂₁H₂₄FN₅O₄
Molecular Weight	429.44 g/mol
Synonyms	7-[(3S,5S)-3-Amino-5-methylpiperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Nemonoxacin acid; Nemonoxacin free acid; ABT-492; TG-873870; (S)-Nemonoxacin; DX-619; LB-20304a
EINECS	Contact for details

Quality Control

Our Nemonoxacin is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC for purity, chiral analysis, and residual solvent determination to ensure it meets high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) confirming identity, purity, and conformance to agreed specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.