Description

2-[[(3Ar,4S,6R,6As)-6-[7-Chloro-5-(Propylthio)-3H-1,2,3-Triazolo[4,5-D]Pyrimidin-3-Yl]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Yl]Oxy]-Ethanol is a sophisticated nucleoside analog intermediate of significant interest in advanced pharmaceutical research and development. Its complex structure, featuring a triazolopyrimidine core and a protected sugar moiety, makes it a critical building block for the synthesis of novel antiviral and anticancer agents. This high-purity compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside analog drugs targeting viral infections and oncology.
• Antiviral Drug Development: Used in research for creating potential therapeutics against DNA and RNA viruses.
• Oncology Research: Serves as a building block for developing targeted cancer therapies that interfere with cellular DNA/RNA synthesis.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Biochemical Research: Acts as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism.

Basic Information

Product Name	2-[[(3Ar,4S,6R,6As)-6-[7-Chloro-5-(Propylthio)-3H-1,2,3-Triazolo[4,5-D]Pyrimidin-3-Yl]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Yl]Oxy]-Ethanol
CAS No.	376608-75-2
Molecular Formula	C17H24ClN5O4S
Molecular Weight	429.92 g/mol
Synonyms	7-Chloro-5-(propylthio)-3-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine (protected form); 2-(((3aR,4S,6R,6aR)-6-(7-Chloro-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)oxy)ethan-1-ol; Nucleoside triazolopyrimidine analog intermediate; Protected nucleoside analog CAS 376608-75-2
EINECS	Contact for details

Quality Control

Our 2-[[(3Ar,4S,6R,6As)-6-[7-Chloro-5-(Propylthio)-3H-1,2,3-Triazolo[4,5-D]Pyrimidin-3-Yl]Tetrahydro-2,2-Dimethyl-4H-Cyclopenta-1,3-Dioxol-4-Yl]Oxy]-Ethanol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.