Description

3-(3,4-Dichloro-Phenyl)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid is a specialized Fmoc-protected amino acid derivative, a critical building block in modern solid-phase peptide synthesis (SPPS). This compound matters because it provides the essential 3,4-dichlorophenylalanine moiety with orthogonal protection, enabling the precise and efficient construction of complex peptides. Pharmaceutical researchers and fine chemical manufacturers need this high-purity intermediate for developing therapeutic peptides, peptidomimetics, and other bioactive molecules where the unique properties of halogenated aromatic side chains are required.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the automated, sequential assembly of custom peptide sequences in drug discovery and development.
• Pharmaceutical Intermediates: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs) for peptide-based therapeutics.
• Research & Development: Used in academic and industrial R&D labs for studying peptide structure-activity relationships (SAR) and creating novel bioactive compounds.
• Peptidomimetic Design: Incorporates the dichlorophenyl group into non-peptide scaffolds to enhance metabolic stability and binding affinity in drug candidates.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation: Can be used to introduce specific chemical handles or fluorophores onto peptides or proteins for diagnostic or targeting applications.

Basic Information

Product Name	3-(3,4-Dichloro-Phenyl)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid
CAS No.	376595-03-8
Molecular Formula	C30H21Cl2NO4
Molecular Weight	530.40 g/mol
Synonyms	Fmoc-3,4-dichloro-DL-phenylalanine; Fmoc-DL-3,4-dichlorophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,4-dichloro-DL-phenylalanine; 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(3,4-dichlorophenyl)propanoic acid; Fmoc-3,4-Cl2-Phe-OH; N-Fmoc-3,4-dichlorophenylalanine; (RS)-2-(Fmoc-amino)-3-(3,4-dichlorophenyl)propionic acid
EINECS	Contact for details

Quality Control

Our 3-(3,4-Dichloro-Phenyl)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-Propionic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and pharmaceutical applications. All materials undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.