Description

Valine, 4,4-Difluoro- (9Ci) is a fluorinated derivative of the essential amino acid L-valine, identified by CAS NO 376359-43-2. This specialized building block is critical for introducing fluorine atoms into peptides and bioactive molecules, enhancing their metabolic stability, lipophilicity, and binding affinity. It is primarily utilized by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel therapeutics and advanced materials.

Application

• Pharmaceutical Intermediate: A key fluorinated building block for the synthesis of novel peptide-based drugs and protease inhibitors.
• Proteomics Research: Used in the study of protein structure and function, particularly in creating fluorinated analogs for 19F NMR spectroscopy.
• Agrochemical Development: Serves as a precursor in the design of advanced herbicides and pesticides with improved environmental profiles.
• Peptide Synthesis: Incorporated into custom peptides to modulate their physical, chemical, and biological properties for research and therapeutic applications.
• Chemical Biology Probes: Utilized in the creation of activity-based probes and diagnostic agents for biological imaging and target engagement studies.
• Material Science: A monomer for developing specialized fluorinated polymers and coatings with unique surface characteristics.

Basic Information

Product Name	Valine, 4,4-Difluoro- (9Ci)
CAS No.	376359-43-2
Molecular Formula	C5H9F2NO2
Molecular Weight	153.13 g/mol
Synonyms	4,4-Difluorovaline; 2-Amino-3-methyl-4,4-difluorobutanoic acid; DL-4,4-Difluorovaline; (RS)-4,4-Difluorovaline; 4,4-Difluoro-DL-valine; 4,4-Difluorovaline (racemic); 4,4-Difluoro-2-amino-3-methylbutyric acid; 4,4-Difluoro-3-methyl-2-aminobutanoic acid
EINECS	Contact for details

Quality Control

Our Valine, 4,4-Difluoro- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	Racemic mixture (DL-)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.