Description

Ethyl 6-Methyl-2-Oxo-4-(1-Phenyl-3-(Thiophen-2-Yl)-1H-Pyrazol-4-Yl)-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the tetrahydropyrimidine class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting specific therapeutic pathways. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of new drug candidates, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug molecules, especially in medicinal chemistry research.
• API Development: Used as a core scaffold for constructing novel Active Pharmaceutical Ingredients with targeted biological activity.
• Chemical Research: Serves as a valuable reagent in academic and industrial laboratories for exploring new heterocyclic chemistry and reaction pathways.
• Preclinical Studies: Supplied in high purity for use in the early-stage development and screening of new therapeutic compounds.
• Custom Synthesis: Acts as a starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis for clients.

Basic Information

Product Name	Ethyl 6-Methyl-2-Oxo-4-(1-Phenyl-3-(Thiophen-2-Yl)-1H-Pyrazol-4-Yl)-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	376358-26-8
Molecular Formula	C22H20N4O3S
Molecular Weight	420.48 g/mol
Synonyms	Ethyl 4-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 4-(1-Phenyl-3-(2-thienyl)-1H-pyrazol-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylic Acid Ethyl Ester; 1,2,3,4-Tetrahydropyrimidine-5-carboxylic acid, 4-[1-phenyl-3-(2-thienyl)-1H-pyrazol-4-yl]-6-methyl-2-oxo-, ethyl ester; 376358-26-8; 4-(1-Phenyl-3-thiophen-2-yl-1H-pyrazol-4-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester.
EINECS	Contact for details

Quality Control

Our Ethyl 6-Methyl-2-Oxo-4-(1-Phenyl-3-(Thiophen-2-Yl)-1H-Pyrazol-4-Yl)-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical intermediates, and our facilities are committed to maintaining the highest levels of quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.