Description

n-{(E)-Amino[(6-Methoxy-4-Methylquinazolin-2-Yl)Amino]Methylidene}-10H-Phenothiazine-10-Carboxamide is a sophisticated heterocyclic compound that serves as a key advanced intermediate in modern pharmaceutical research and development. Its molecular architecture, combining quinazoline and phenothiazine pharmacophores, makes it a valuable scaffold for creating novel bioactive molecules. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of potential therapeutic agents targeting central nervous system disorders, oncology, and other complex disease pathways.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those targeting kinase inhibition or receptor modulation.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new chemical entities with optimized potency and selectivity.
• Biochemical Probe Development: Serves as a core structure for creating labeled compounds or probes to study biological pathways and protein interactions.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	n-{(E)-Amino[(6-Methoxy-4-Methylquinazolin-2-Yl)Amino]Methylidene}-10H-Phenothiazine-10-Carboxamide
CAS No.	375842-02-7
Molecular Formula	C26H21N7O2S
Molecular Weight	495.56 g/mol
Synonyms	10H-Phenothiazine-10-carboxamide, N-[(1E)-amino[(6-methoxy-4-methyl-2-quinazolinyl)amino]methylene]-; (E)-N-(Amino((6-methoxy-4-methylquinazolin-2-yl)amino)methylene)phenothiazine-10-carboxamide; CAS 375842-02-7; Quinazoline-phenothiazine carboxamide derivative; Advanced pharmaceutical intermediate 375842-02-7
EINECS	Contact for details

Quality Control

Every batch of n-{(E)-Amino[(6-Methoxy-4-Methylquinazolin-2-Yl)Amino]Methylidene}-10H-Phenothiazine-10-Carboxamide is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC purity, identity confirmation (IR, NMR), and impurity profiles. Our quality commitment ensures material consistency and traceability, supporting your regulatory and research requirements. Specifications can be aligned with current Good Manufacturing Practice (cGMP) standards for advanced pharmaceutical intermediates upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.