Description

5-Bromo-2-(4-Boc-piperazin-1-yl)pyrimidine is a high-purity, advanced pharmaceutical intermediate featuring a versatile pyrimidine core functionalized with a bromine atom and a Boc-protected piperazine moiety. This compound is critical for medicinal chemistry research and development, serving as a key building block for the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing kinase inhibitors and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, particularly in oncology and CNS research.
• Kinase Inhibitor Development: Used as a core scaffold or functionalized fragment for designing and synthesizing potent and selective kinase inhibitors.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable bromine and protected amine sites.
• Custom Synthesis Building Block: Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects requiring specific heterocyclic architectures.
• Chemical Biology Probes: Serves as a starting material for creating chemical probes used to study biological pathways and protein function.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and drug discovery methodologies.

Basic Information

Product Name	5-Bromo-2-(4-Boc-piperazin-1-yl)pyrimidine
CAS No.	374930-88-8
Molecular Formula	C13H18BrN5O2
Molecular Weight	356.22 g/mol
Synonyms	1-Boc-4-(5-Bromo-2-pyrimidinyl)piperazine; tert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate; 5-Bromo-2-[1-(tert-butoxycarbonyl)piperazin-4-yl]pyrimidine; 2-(4-Boc-Piperazin-1-yl)-5-bromopyrimidine; 5-Bromo-2-(N-Boc-piperazinyl)pyrimidine; 374930-88-8; 1-(tert-Butoxycarbonyl)-4-(5-bromo-2-pyrimidinyl)piperazine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(4-Boc-piperazin-1-yl)pyrimidine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.